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Clara L Kielkopf Selected Research

RNA Precursors (Precursor, mRNA)

1/2021A synthetic small molecule stalls pre-mRNA splicing by promoting an early-stage U2AF2-RNA complex.
12/2020Representative cancer-associated U2AF2 mutations alter RNA interactions and splicing.
11/2019Structures of SF3b1 reveal a dynamic Achilles heel of spliceosome assembly: Implications for cancer-associated abnormalities and drug discovery.
1/2018Insights from structures of cancer-relevant pre-mRNA splicing factors.
12/2017Cancer-Associated Mutations Mapped on High-Resolution Structures of the U2AF2 RNA Recognition Motifs.
1/2017Splicing Factor Mutations in Myelodysplasias: Insights from Spliceosome Structures.
12/2016Unmasking the U2AF homology motif family: a bona fide protein-protein interaction motif in disguise.

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Clara L Kielkopf Research Topics

Disease

8Neoplasms (Cancer)
01/2021 - 06/2014
3Myelodysplastic Syndromes (Myelodysplastic Syndrome)
12/2017 - 12/2016
2Hematologic Neoplasms (Hematological Malignancy)
12/2020 - 11/2019
1Acute Erythroblastic Leukemia (Erythroleukemia)
01/2022
1Infections
01/2020
1Acquired Immunodeficiency Syndrome (AIDS)
01/2019
1Leukemia
12/2017
1Adenocarcinoma of Lung
10/2016
1Lung Neoplasms (Lung Cancer)
10/2016
1Neurofibromatoses (Neurofibromatosis)
12/2014
1Inborn Genetic Diseases (Disease, Hereditary)
12/2014
1Retinitis Pigmentosa (Pigmentary Retinopathy)
12/2014

Drug/Important Bio-Agent (IBA)

8RNA Splicing FactorsIBA
12/2020 - 06/2014
7RNA Precursors (Precursor, mRNA)IBA
01/2021 - 12/2016
2RNA (Ribonucleic Acid)IBA
12/2020 - 12/2017
1UridineIBA
01/2022
1NucleotidesIBA
01/2022
1Proteins (Proteins, Gene)FDA Link
01/2020
1Pharmaceutical PreparationsIBA
11/2019
1U2 small nuclear RNA (U2 snRNA)IBA
01/2019
1RNA Splice SitesIBA
12/2017
1Mutant Proteins (Protein, Mutant)IBA
10/2016
1purineIBA
12/2014
1Amino AcidsFDA Link
12/2014
1Splicing Factor U2AFIBA
12/2014
1Protein Isoforms (Isoforms)IBA
06/2014
1Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
06/2014